jak inhibitor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2460	JAK 3 inhibitor IV	ZM 39923 hydrochloride,Jak3 inhibitor IV	EGFR , Others , JAK
	JAK 3 inhibitor IV (ZM 39923 hydrochloride) is a JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.		EGFR , Others , JAK
T11710	JAK-IN-5		JAK
	JAK-IN-5 is a JAK inhibitor.		JAK
T3080	Pyridone 6	Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,JAK Inhibitor I	Tyrosine Kinases , JAK
	Pyridone 6 (JAK Inhibitor)(CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM); displaying significantly weaker affinities (130 nM to 10 mM...		Tyrosine Kinases , JAK
T38624	Fosifidancitinib		JAK
	Fosifidancitinib is a potent inhibitor of JAK 1 and JAK 3.		JAK
T5492	JAK3-IN-6		JAK
	JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM		JAK
T4672	Brevilin A		Apoptosis , Anti-infection , JAK , STAT , Autophagy
	Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT si...		Apoptosis , Anti-infection , JAK , STAT , Autophagy
T3069	AZD-1480		JAK
	AZD1480 is a novel ATP-competitive JAK2 inhibitor (IC50: 0.26 nM), selectivity act against Tyk2 and JAK3, and to a smaller extent against JAK1. AZD1480 has been used in trials studying the treatment of Solid Malignancies...		JAK
T39113L	Povorcitinib phosphate		JAK
	Povorcitinib phosphate is a selective JAK1 inhibitor and can be used in studies about the treatment of cutaneous lupus erythematosus and Lichen planus.		JAK
T4210	SAR-20347	SAR20347	Tyrosine Kinases , JAK
	SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).		Tyrosine Kinases , JAK
T6790	BMS-911543	BMS911543	Tyrosine Kinases , Histone Methyltransferase , JAK
	BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.		Tyrosine Kinases , Histone Methyltransferase , JAK
T5091	FM-381	FM381	JAK
	FM381 is a potent covalent reversible inhibitor of JAK3. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.		JAK
T6122	CEP-33779	CEP33779	JAK
	CEP-33779 is a novel and selective inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.		JAK
T2156	WP1066		Apoptosis , JAK , STAT
	WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3. WP1066 has been used in trials studying the treatment of Melanoma, Bra...		Apoptosis , JAK , STAT
T6838	FLLL32		Apoptosis , JAK , STAT
	FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).		Apoptosis , JAK , STAT
T8546	BD750		JAK , STAT
	BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM in mouse and human T cells, respectively)		JAK , STAT
TJS1779	Protosappanin A	PTA	NADPH-oxidase , IL Receptor , IκB/IKK , TNF , NF-κB , TLR , ROS , COX , HIV Protease , JAK , NO Synthase , STAT
	Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IÎºB/NF-ÎºB inflammation signal pathway; it exerts anti-neuroinflammatory ...
T1929	Filgotinib	GLPG0634	Tyrosine Kinases , JAK
	Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.		Tyrosine Kinases , JAK
T3042	JAK2 Inhibitor V	JAK2 Inhibitor V Z3,Z3	JAK
	JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.		JAK
T10431	Golidocitinib	AZD4205	JAK
	Golidocitinib (AZD4205) is a selective JAK1 inhibitor (IC50: 73 nM) and weakly inhibits JAK2/JAK3 (IC50: >14.7, >30 μM).		JAK
TQ0010	Brepocitinib	PF-06700841	Tyrosine Kinases , JAK
	Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).		Tyrosine Kinases , JAK